ObjectiveTo understand the current status of knowledge, attitude, and practice of oxygen therapy for acute myocardial infarction (AMI) among medical staff in cardiovascular medicine department and the influencing factors for their oxygen therapy behavior. MethodsA total of 517 medical staff in cardiovascular medicine department were investigated by using the self-designed knowledge, attitude, and practice questionnaire for medical staff AMI oxygen therapy. Score of AMI oxygen therapy behavior dimension was compared between medical staff with different characteristics, and the influencing factors for their oxygen therapy behavior were analyzed. ResultsThere was statistically significant difference in score of AMI oxygen therapy behavior dimension between medical staff in cardiovascular medicine department with different educational levels (P<0.05). Knowledge, attitude, and practice scores in various dimensions and total score of knowledge, attitude, and practice in AMI oxygen therapy among medical staff in cardiovascular medicine department were at the medium level, and AMI oxygen therapy behavior dimension score positively correlated with scores of AMI oxygen therapy knowledge dimension and AMI oxygen therapy attitude dimension among medical staff in cardiovascular medicine department (P<0.05). The results of multivariate linear regression analysis revealed that educational level and score of AMI oxygen therapy attitude dimension were the influencing factors for AMI oxygen therapy behavior among medical staff in cardiovascular medicine department (P<0.05). ConclusionKnowledge, attitude, and practice scores in various dimensions and total score of knowledge, attitude, and practice in AMI oxygen therapy among medical staff in cardiovascular medicine department are at the medium level. Educational level and oxygen therapy attitude are the influencing factors for their oxygen therapy behavior.