Objective To investigate the current status of anorexia in patients with chronic heart failure and its influencing factors. Methods A total of 160 patients with chronic heart failure were selected by using the convenience sampling method. The clinical data inventory, Functional Assessment of Anorexia/Cachexia Therapy⁃Anorexia Cachexia Subscale in Chinese version, Pittsburgh Sleep Quality Index (PSQI) scale, Hospital Anxiety and Depression Scale were used to perform investigation on them. The multivariate Logistic regression model was used to analyze the factors for affecting the occurrence of anorexia in patients with chronic heart failure. Results The incidence rate of anorexia among 160 patients with chronic heart failure was 50.63% (81/160). The results of multivariate Logistic regression analysis revealed that household per capita monthly income, cardiac function classification of New York Heart Association (NYHA), states of concomitant digestive system diseases, red blood cell counts, blood potassium level, and total score of PSQI scale were the influencing factors for the occurrence of anorexia in patients with chronic heart failure (P<0.05). Conclusion The incidence rate of anorexia is relatively high in patients with chronic heart failure, household per capita monthly income, NYHA cardiac function classification, states of concomitant digestive system diseases, red blood cell counts, blood potassium level, and sleep quality are the influencing factors for patients with chronic heart failure suffering from anorexia.