ObjectiveTo investigate the levels of serum secreted frizzled related protein 4 (SFRP4) and galectin 3 (Gal-3) in patients with diabetic foot and their clinical significance. MethodsA total of 100 patients with diabetic foot were selected as the diabetic foot group, and they were further assigned to mild group (34 cases), moderate group (43 cases), or severe group (23 cases) according to the Wagner classification. Another 100 patients with type 2 diabetes mellitus without diabetic foot were selected as the control group during the same period. The levels of serum SFRP4 and Gal-3 were detected by the ELISA. The multivariate Logistic regression model was applied to analyze the influencing factors for the occurrence of diabetic foot in patients with type 2 diabetes mellitus. The receiver operating characteristic (ROC) curve was used to evaluate predictive value of serum SFRP4 and Gal-3 levels for the occurrence of diabetic foot in patients with type 2 diabetes mellitus. ResultsThe levels of urinary microalbumin/creatinine, serum interleukin (IL)-1β, IL-6, tumor necrosis factor α (TNF-α), C-reactive protein (CRP), SFRP4, and Gal-3 in the diabetic foot group were higher than those in the control group (P＜0.05). Compared with the mild group, serum SFRP4 and Gal-3 levels of the moderate group and the severe group were elevated (P＜0.05); furthermore, compared with the moderate group, serum SFRP4 and Gal-3 levels in the severe group were elevated (P＜0.05). The results of multivariate Logistic regression analysis revealed that serum IL-1β, TNF-α, SFRP4, and Gal-3 levels were the influencing factors for the occurrence of diabetic foot in patients with type 2 diabetes mellitus (P＜0.05). The results of ROC curve analysis indicated that areas under the curve of serum SFRP4 and Gal-3 levels for alone and jointly predicting the occurrence of diabetic foot were 0.788, 0.781, and 0.862, respectively, therein, area under the curve of the combined prediction of the two was larger than that of the single prediction of serum SFRP4 and Gal-3 levels (P＜0.05). ConclusionSerum SFRP4, Gal-3 levels in patients with diabetic foot are elevated, which are closely related to diabetic foot severity, and they are all the influencing factors for the occurrence of diabetic foot in patients with type 2 diabetes mellitus. The combined prediction of the two for predicting the occurrence of diabetic foot exerts relatively high efficiency.

无