目的探讨老年下肢骨折术后患者发生亚谵妄综合征(SSD)的现状,并分析其影响因素。方法选取237例老年下肢骨折手术患者作为研究对象,术后每日采用中文版意识模糊评估量表(CAM)评估患者术后7 d内的SSD发生情况,并收集患者一般资料及术前禁食时间、麻醉方式、手术时间、术中出血量、生活自理能力依赖程度、术前简易智力状态检查量表评分、术前抑郁自评量表(SDS)评分、是否使用自控式镇痛治疗等临床资料和血生化指标(血红蛋白、血白蛋白、K+、Na+、Cl-、Ca2+)水平。采用多因素Logistic回归模型分析老年下肢骨折术后患者发生SSD的影响因素。 结果237例老年下肢骨折术后患者SSD的发生率为52.32%,其中91.93%的SSD症状发生在术后72 h内,有42.74%的SSD患者同时存在谵妄。同时存在谵妄的SSD患者中,32.08%的患者SSD症状出现在谵妄发作之前并最终进展为谵妄,67.92%的患者SSD症状出现在2次谵妄发作的间歇期或谵妄状态结束后。SSD中位发生次数为2次,总持续时间为(35.89±16.78)h。中文版CAM的4个谵妄核心特征中以“意识水平改变”出现频次最多,占比为42.68%。多因素Logistic回归分析结果显示,年龄、术前SDS评分、术前禁食时间、低钙血症、生活自理能力依赖程度、使用自控式镇痛治疗是老年下肢骨折术后患者发生SSD的影响因素(P<0.05)。结论老年下肢骨折术后患者SSD发生率较高,高发期为术后72 h内。年龄越大、术前禁食时间越长、生活自理能力依赖程度越高、术前SDS评分越高、使用自控式镇痛治疗及存在低钙血症的老年下肢骨折手术患者术后更易发生SSD,医护人员应对这些影响因素进行早期评估和筛查,以降低SSD的发生率,避免其进展为谵妄。
ObjectiveTo investigate the current status of elderly patients suffering from subsyndromal delirium (SSD) after lower extremity fracture surgery, and to analyze its influencing factors.MethodsA total of 237 elderly patients undergoing lower extremity fracture surgery were selected as the research subjects. The occurrence of SSD within 7 days after surgery was evaluated daily in patients by employing the Confusion Assessment Method (CAM) in Chinese version, and the general data, as well as clinical data in terms of preoperative fasting time, anesthesia method, operation duration, intraoperative bleeding volume, dependence degree of daily living self-care ability, preoperative Mini-Mental State Examination scale score, preoperative Self-Depression Scale (SDS) score, presence of self-controlled analgesia, etc., and blood biochemical indices (hemoglobin, albumin, K+, Na+, Cl-, and Ca2+) levels were collected in patients. The influencing factors for elderly patients suffering from SSD after lower extremity fracture surgery were analyzed by using the multivariate Logistic regression model. ResultsThe incidence rate of SSD was 52.32% among 237 elderly patients after lower extremity fracture surgery, of which 91.93% of SSD symptom appeared within 72 hours after surgery, and 42.74% of SSD patients suffered from delirium at the same time. In SSD patients simultaneously suffering from delirium, SSD symptom appeared in 32.08% of patients before the onset of delirium and eventually progressed to delirium, and SSD symptom appeared in 67.92% of patients in the intermittent stage between two episodes of delirium, or appeared after the end of delirium status. The median frequency of SSD occurred was 2 times, and the total duration was (35.89±16.78) hours. Among the 4 core delirium features of CAM in Chinese version, "change of consciousness level" most frequently occurred, accounting for 42.68%. The results of multivariate Logistic regression analysis revealed that age, preoperative SDS score, preoperative fasting time, hypocalcemia, dependence degree of daily living self-care ability, and use of self-controlled analgesia were the influencing factors for elderly patients suffering from SSD after lower extremity fracture surgery (P<0.05). ConclusionThe incidence rate of elderly patients suffering from SSD after lower extremity fracture surgery is relatively high, the high-incidence period is within 72 hours after surgery. Older age, longer preoperative fasting time, higher dependence degree of daily living self-care ability, higher preoperative SDS score, use of self-controlled analgesia, and presence of hypocalcemia are more likely to develop SSD after lower extremity fracture surgery in elderly patients. Medical staff should conduct early evaluation and screening on these influencing factors to decrease the incidence rate of SSD, and avoid its progression to delirium.