ObjectiveTo analyze the allergic conditions in children with bronchial asthma (hereinafter referred to as asthma), and their relation with age and peripheral blood eosinophil (EOS) counts based on serum specific IgE (sIgE) level. MethodsThe clinical data of 120 children with asthma were retrospectively analyzed, and they were divided into group A (1 year old＜age≤3 years old, 15 cases), group B (3 years old＜age≤6 years old, 56 cases), or group C (6 years old＜age≤15 years old, 49 cases) according to children′s age. Serum total IgE positive states, sIgE positive states of inhaled and ingestive allergen in children with asthma were analyzed. Serum total IgE level, inhaled and ingestive allergen sIgE levels were compared between children of the 3 groups. The relation of allergy degree of children with Dermatophagoides pteronyssinus/Dermatophagoides farinae sIgE positive with age and peripheral blood EOS counts was analyzed. Results(1) Among 120 children with asthma, serum total IgE of 110 (91.67%) children was positive; in addition, the positive rates of serum total IgE in groups A, B, and C were 73.33% (11/15), 91.07% (51/56), and 97.96% (48/49), respectively, and group C exhibited a higher positive rate of serum total IgE as compared with group A (P＜0.05). (2) Among 120 children with asthma, the case number of Dermatophagoides pteronyssinus/Dermatophagoides farinae sIgE positive was the most. Children with asthma in group A were mainly allergic to Dermatophagoides pteronyssinus/Dermatophagoides farinae, fungal combination, and milk, asthmatic children in group B were mainly allergic to Dermatophagoides pteronyssinus/Dermatophagoides farinae, egg, and soy, and asthmatic children in group C were mainly allergic to Dermatophagoides pteronyssinus/Dermatophagoides farinae, cockroach, and dog hairs. The positive rate of Dermatophagoides pteronyssinus/Dermatophagoides farinae sIgE of asthmatic children in group C was higher than that in groups A and B, while the positive rate of fungal combination sIgE of children with asthma in group A was higher than that in group C (P＜0.05). (3) A total of 67.06% (57/85) asthma children with Dermatophagoides pteronyssinus/Dermatophagoides farinae sIgE positive were extraordinarily severe allergy. In asthmatic children with Dermatophagoides pteronyssinus/Dermatophagoides farinae sIgE positive, allergy degree positively correlated with peripheral blood EOS counts, and allergy degree of Dermatophagoides pteronyssinus/Dermatophagoides farinae was more severe in group C than in groups A and B (P＜0.05). ConclusionSerum total IgE level is elevated in asthmatic children, and with the increase of age, the general trend is increasing. Dermatophagoides pteronyssinus/Dermatophagoides farinae are leading allergens for children with asthma, and the common allergens in asthmatic children gradually transition from mixed allergens to inhaled allergens with the increase of age. Allergy degree in asthmatic children with Dermatophagoides pteronyssinus/Dermatophagoides farinae allergy increases with age and relates to peripheral blood EOS counts. Peripheral blood EOS counts can be used as a reference index to evaluate allergy degree in asthmatic children with Dermatophagoides pteronyssinus/Dermatophagoides farinae allergy.

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