ObjectiveTo systemically evaluate the effectiveness and safety of percutaneous endoscopic lumbar discectomy (PELD) assisted by 3D printing model technique for the treatment of lumbar disc herniation. MethodsLiterature related to PELD assisted by 3D printing model technique for the treatment of lumbar disc herniation were collected through retrieving the databases of Wanfang Data Knowledge Service Platform, VIP, China National Knowledge Infrastructure, China Biology Medicine disc, PubMed, The Cochrane Library, and Embase, etc. After screening literature, extracting data, and evaluating quality, the Stata/SE 12.0 software was used for Meta-analysis. ResultsA total of 10 literature was enrolled. The results of Meta-analysis revealed that compared with routine PELD, PELD assisted by 3D printing model technique exhibited lower Visual Analogue Scale score, Oswestry disability index, and incidence rate of complications, less numbers of puncture and X-ray fluoroscopy, and shorter operation duration. ConclusionPELD assisted by 3D printing model technique for the treatment of lumbar disc herniation can relieve patients′ pain, ameliorate lumbar motion function, reduce numbers of puncture and X-ray fluoroscopy, shorten operation duration, and decrease the incidence rate of complications.