广西医学

目的探讨理中汤加味配合腹针治疗脾胃虚寒型十二指肠溃疡患者的效果及其对血清炎症因子、胃肠激素水平的影响。方法将136例脾胃虚寒型十二指肠溃疡患者随机分为研究组和对照组，各68例。给予对照组四联疗法治疗，研究组在对照组治疗基础上采用理中汤加味配合腹针治疗。比较两组患者治疗前后的中医证候积分、血清炎症因子［转化生长因子β1（TGF-β1）、白细胞介素8（IL-8）］水平、胃肠激素（血浆生长抑素、血浆胃动素、血清胃泌素）水平，以及两组的中医证候疗效、胃镜疗效、幽门螺杆菌（Hp）清除率、不良反应发生情况。结果治疗后，研究组的中医证候总有效率、胃镜总有效率高于对照组，中医证候总积分低于对照组（P＜0.05）。治疗后，两组患者的血清TGF-β1、血清IL-8、血浆胃动素、血清胃泌素水平较治疗前降低，血浆生长抑素水平较治疗前升高，且研究组血清TGF-β1、血清IL-8、血浆胃动素、血清胃泌素水平低于对照组，血浆生长抑素水平高于对照组（P＜0.05）。两组患者的Hp清除率、不良反应发生率差异无统计学意义（P＞0.05）。结论在四联疗法基础上采用理中汤加味配合腹针治疗脾胃虚寒型十二指肠溃疡，能改善患者的症状，促进溃疡愈合，调节胃肠激素、血清炎症因子水平，效果显著，安全性高。

ObjectiveTo investigate the effect of modified Lizhong Decoction combined with abdominal acupuncture for the treatment of patients with duodenal ulcer in type of cold in spleen and stomach from deficiency and its influence on serum inflammatory and gastrointestinal hormones levels. MethodsA total of 136 patients with duodenal ulcer in type of cold in spleen and stomach from deficiency were randomly divided into study group or control group, with 68 cases in each group. The control group was treated with quadruple regimen, based on which the study group received modified Lizhong Decoction combined with abdominal acupuncture for treatment. The Traditional Chinese Medicine syndromes score, serum inflammatory factors in terms of transforming growth factor β1 (TGF-β1), interleukin 8 (IL-8) levels, and gastrointestinal hormones with respect to plasma somatostatin, plasma motilin, and serum gastrin levels before and after treatment, as well as Traditional Chinese Medicine syndromes efficacy, gastroscopic efficacy, the clearance rate of Helicobacter pylori (Hp), and the occurrence of adverse reactions were compared between patients of the two groups. ResultsAfter treatment, the total effective rates of Traditional Chinese Medicine syndromes and gastroscopy of the study group were higher than those of the control group, whereas the total score of Traditional Chinese Medicine syndromes were lower than that of the control group (P＜0.05). After treatment, the levels of serum TGF-β1, serum IL-8, plasma motilin, serum gastrin of the two groups were decreased, whereas plasma somatostatin level was elevated as compared with before treatment, and the study group exhibited lower levels of serum TGF-β1, serum IL-8, plasma motilin, serum gastrin, while a higher level of plasma somatostatin as compared with the control group (P＜0.05). There was no statistically significant difference in the clearance rate of Hp, and incidence rate of adverse reactions between patients of the two groups (P＞0.05). ConclusionOn the basis of quadruple regimen, modified Lizhong Decoction combined with abdominal acupuncture for the treatment of duodenal ulcer in type of cold in spleen and stomach from deficiency can ameliorate patients′ symptoms, promote ulcer healing, regulate gastrointestinal hormones and serum inflammatory factors levels, exerting remarkable effects and a high safety.