ObjectiveTo investigate the expressions of serum miR-202-5p and proprotein convertase subtilisin/kexin 9 (PCSK9) and their clinical significance. MethodsA total of 79 patients with AD were selected as AD group, and 39 check-up healthy individuals as control group. The levels of serum miR-202-5p and PCSK9 were detected in both groups. The correlation of serum miR-202-5p and PCSK9 levels with serum amyloid β-protein (Aβ)1-40 and Aβ1-42 levels, as well as Mini-Mental State Examination (MMSE) scale score in AD patients was analyzed, and the diagnostic value of serum miR-202-5p and PCSK9 levels single and combined on AD was evaluated. ResultsThe levels of serum Aβ1-42 and miR-202-5p, and MMSE scale score were lower in the AD group than in the control group, while serum Aβ1-40 and PCSK9 levels were higher in the AD group than in the control group (P＜0.05). The level of serum miR-202-5p negatively correlated with serum Aβ1-40 and PCSK9 levels in AD patients, whereas positively correlated with serum Aβ1-42 level and MMSE scale score (P＜0.05); furthermore, serum PCSK9 level positively correlated with serum Aβ1-40 level, while negatively correlated with serum Aβ1-42 level and MMSE scale score (P＜0.05). Area under the curve of serum miR-202-5p and PCSK9 levels for jointly diagnosing AD was larger than that of single diagnosis of the two as above (P＜0.05). ConclusionSerum miR-202-5p level is decreased, whereas serum PCSK9 level is elevated in AD patients. Level changes of the two may be related to Aβ deposition and cognitive dysfunction of AD patients, which may be regarded as adjuvant diagnostic indices for AD.

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