广西医学

目的探讨松烟墨疗法治疗寒湿痹阻型膝骨关节炎（KOA）的临床疗效。方法选取99例寒湿痹阻型KOA患者作为研究对象，按随机数字表法将其分为墨疗组、对照组和西药组，每组33例。墨疗组采用松烟墨进行治疗，对照组采用不含药物的安慰剂进行治疗，西药组采用口服塞来昔布胶囊进行治疗。比较治疗前后3组患者的西安大略和麦克马斯特大学骨关节炎指数（WOMAC）评分（疼痛程度评分、僵硬症状评分、关节功能评分、总分），血清炎症因子［白细胞介素（IL）-6、IL-1、肿瘤坏死因子α（TNF-α）、基质金属蛋白酶13（MMP13）］水平，以及膝关节皮温的变化情况。结果治疗后，墨疗组和西药组的WOMAC总分、疼痛程度评分、僵硬症状评分和关节功能评分，以及血清IL-6、IL-1、TNF-α和MMP13 水平较治疗前降低（P＜0.05），且墨疗组和西药组的WOMAC总分、疼痛程度评分低于对照组，墨疗组的血清IL-6、IL-1、TNF-α和MMP13水平低于西药组（P＜0.05）。治疗前后，3组的膝关节皮温差异无统计学意义（P＞0.05）。结论松烟墨疗法能显著降低寒湿痹阻型KOA患者的血清炎症因子水平，有效改善关节疼痛、僵硬等症状，临床疗效良好，值得应用推广。

ObjectiveTo investigate the clinical efficacy of pine-soot ink therapy for the treatment of knee osteoarthritis (KOA) in blockage from cold-dampness type. MethodsA total of 99 KOA patients in blockage from cold-dampness type were selected as the research subjects, and they were divided into ink therapy group, control group, or Western Medicine group according to the random number table method, with 33 cases in each group. The ink therapy group was treated with pine-soot ink, the control group was treated with drug-free placebo, and the Western Medicine group was orally administrated Celecoxib Capsule for treatment. The Western Ontario and McMaster University Osteoarthritis Index (WOMAC) score (scores for pain degree, stiffness symptom, joint function, and total score), serum inflammatory factors levels with respect to interleukin (IL)-6, IL-1, tumor necrosis factor α (TNF-α), matrix metalloproteinase 13 (MMP13), and the changes of knee joint skin temperature before and after treatment were compared between patients of the three groups. ResultsAfter treatment, the total score of WOMAC, pain degree score, stiffness symptom score, joint function score, and serum IL-6, IL-1, TNF-α, and MMP13 levels in the ink therapy group and the Western Medicine group were decreased as compared with before treatment (P＜0.05), and the total score of WOMAC and pain degree score in the ink therapy group and the Western Medicine group were lower than those in the control group; moreover, the levels of serum IL-6, IL-1, TNF-α, and MMP13 in the ink therapy group were lower than those in the Western Medicine group (P＜0.05). There was no statistically significant difference in knee joint skin temperature between the three groups (P＞0.05).ConclusionPine-soot ink therapy can significantly decrease the levels of serum inflammatory factors in KOA patients in blockage from cold-dampness type, effectively ameliorate joint pain, stiffness, and other symptoms, exerting a favorable clinical efficacy, and it is worthy of application and promotion.