ObjectiveTo analyze the medication rule of Traditional Chinese and Zhuang Medicine of Huang Guodong Professor for treating renal edema by employing real-world data mining technique. MethodsPrescriptions from Huang Guodong Professor for treating 198 patients with renal edema were collected from January 2020 to February 2023. The database of prescriptions was established by employing the Microsoft Excel 2019 software. The cloud platform of Gujin Yian V2.3.5 was use to perform analyses of frequency, association rule, cluster, and complex network on prescriptions messages. ResultsA total of 112 effective prescriptions for the treatment of renal edema were enrolled, involving 128 flavors of Traditional Chinese and Zhuang Medicines. The top 5 most frequently used drugs were Orthosiphon aristatus, Polygala fallax, Ligustrum lucidum, Galium spurium, and Eclipta prostrata, drug properties were mainly moderate, warm, and cold, drug flavors were mainly sweet, bitter, and acrid, drug meridians were mainly liver meridian, renal meridian, and spleen meridian; furthermore, the top 3 most frequently used effects were urine excretion to strain off dampness, heat and toxic materials clearing, and heat clearing to remove dampness. A total of 15 association rules of different drug combinations were obtained by the drug association rule analysis, and the top 3 in support degree were Eclipta prostrata-Ligustrum lucidum, Orthosiphon aristatus-Polygala fallax, and Orthosiphon aristatus-Galium spurium. A total of 4 cluster combinations were acquired by the cluster analysis. The core drugs of 112 effective prescriptions were Ligustrum lucidum, Eclipta prostrata, Orthosiphon aristatus, Polygala fallax, Galium spurium, Hedysarum multijugum, Jujubae fructus, Artemisiae scopariae herba, Glycyrrhiza uralensis, Poria cocos, Coix lacryma-jobi, Panax notoginseng, and Radix rehmanniae preparata. ConclusionMedications of Traditional Chinese and Zhuang Medicine of Huang Guodong Professor for treating renal edema are mainly heat clearing to remove dampness, urine excretion to strain off dampness, and blood circulation promoting to remove stagnation, and at the same time the healthy qi reinforcing and deficiency tonifying, the spleen invigorating and qi replenishing, the kidney reinforcing to control seminal emission, and the liver and kidney tonifying.

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