ObjectiveTo explore the medication rules of Traditional Chinese Medicine for the treatment of hypertension and concomitant depression based on data mining technique. MethodsLiterature related to Traditional Chinese Medicine for treating hypertension and concomitant depression was retrieved form the China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, and VIP database, and prescriptions and their Traditional Chinese Medicine contained for the treatment of hypertension and concomitant depression were collected. The Microsoft Excel 2019 software was used to statistically describe on the use frequency, drug property, drug flavor, meridian entry, and effect of Traditional Chinese Medicine. The association rule analysis was performed on high-frequency Traditional Chinese Medicines (Traditional Chinese Medicines with use frequency≥20 times) by using the SPSS Clementine 12.0 software. The systematic cluster analysis was performed on high-frequency Traditional Chinese Medicines by employing the SPSS Statistics 25.0 software. ResultsA total of 153 literature was enrolled, and there were 153 prescriptions in total, concerning 148 flavors of Traditional Chinese Medicines. There were 34 flavors of high-frequency Traditional Chinese Medicines in total, therein the top 5 Traditional Chinese Medicines with the highest use frequency were Poria cocos, Angelica sinensis radix, Atractylodes macrocephala, Licorice, and Gardenia fructus. The drug properties of 148 flavors of Traditional Chinese Medicines were mainly warm, pathogenic cold, and moderate, drug flavors were mainly sweet, bitter, and acrid, meridian entries were mainly liver meridian, heart meridian, spleen meridian, lung meridian, and renal meridian, drug effects were mainly tonifying and replenishing, mind calming, heat clearing, liver pacifying to subside internal wind, and the exterior releasing. A total of 22 groups of two-drug pair, and 40 groups of three-drug goup were obtained through the association rule analysis, therein the two-drug pairs with a relatively high support were Angelica sinensis radix→Atractylodes macrocephala, Ziziphi spinosae semen→Angelica sinensis radix, the two-drug pairs with a relatively high confidence were Ossa draconis→Concha ostreae, Menthae herba→Angelica sinensis radix; in addition, the three-drug groups with a relatively high support were Atractylodes macrocephala+Angelica sinensis radix→Poria cocos, Ziziphi spinosae semen+Angelica sinensis radix→Atractylodes macrocephala, the three-drug groups with a relatively high confidence were Zingiber officinale roscoe+Atractylodes macrocephala→Angelica sinensis radix, Ziziphi spinosae semen+Atractylodes macrocephala→Angelica sinensis radix. By systematic cluster analysis, 34 high-frequency Traditional Chinese Medicines were clustered into 6 categories. ConclusionThe core drugs of Traditional Chinese Medicine for the treatment of hypertension and concomitant depression are mainly from Guipi Decoction, taking tonifying and replenishing qi and blood, liver smoothing to remove stagnancy of liver qi, and mind calming as the therapeutic principle.

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