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论著.中医药与民族医药诊疗 | 更新时间:2023-11-14
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加味归肾丸联合耳穴压豆对卵巢储备功能减退合并不孕症患者的治疗效果
Therapeutic effect of modified Guishen Pills combined with auricular acupoint pressing with bean for patients with diminished ovarian reserve and concomitant infertility

广西医学 2023第45卷17期 页码:2093-2102

作者机构:黎源,本科,副主任医师,研究方向:妇科内分泌性疾病的中医药治疗方法。

基金信息:广西壮族自治区中医药管理局自筹经费科研课题(GXZYZ20210100)

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目的探讨加味归肾丸联合耳穴压豆对卵巢储备功能减退(DOR)合并不孕症患者的治疗效果。方法将120例DOR合并不孕症患者随机分为观察组和对照组,每组60例。两组均接受常规治疗,对照组在常规治疗基础上采用加味归肾丸治疗,观察组在常规治疗基础上采用加味归肾丸联合耳穴压豆治疗。比较两组患者治疗前后的中医证候积分、超声指标[窦卵泡计数(AFC)、卵巢动脉血流阻力指数、卵巢体积],以及治疗总有效率和随访1年内的妊娠情况(妊娠率、活产率、流产率)。结果治疗后,两组的中医证候积分、卵巢动脉血流阻力指数较治疗前降低,AFC、卵巢体积较治疗前增加,且观察组的上述指标优于对照组(P<0.05);观察组的治疗总有效率、妊娠率高于对照组(P<0.05)。结论加味归肾丸联合耳穴压豆治疗DOR合并不孕症患者的疗效显著,可以有效改善患者的临床症状、卵巢功能,增加患者的妊娠成功率。
ObjectiveTo investigate the therapeutic effect of modified Guishen Pills combined with auricular acupoint pressing with bean for patients with diminished ovarian reserve (DOR) and concomitant infertility. MethodsA total of 120 patients with DOR and concomitant infertility were randomly divided into observation group or control group, with 60 cases in each group. Both groups were given conventional therapy, based on which the control group received modified Guishen Pills for treatment, and the observation group was treated with modified Guishen Pills combined with auricular acupoint pressing with bean on the basis of conventional therapy. The Traditional Chinese Medicine syndrome score, and ultrasonic indices in terms of antral follicle counts (AFC), ovarian arterial flow resistance index, ovarian volume before and after treatment, as well as the total effective rate of treatment, pregnancy within 1 year (the rates of pregnancy, liver birth, and abortion) of follow-up were compared between patients of the two groups. ResultsAfter treatment, the Traditional Chinese Medicine syndrome score and ovarian arterial flow resistance index in the two groups were lower than those before treatment, AFC and ovarian volume were increased as compared with before treatment, and the aforesaid indicators in the observation group were superior to those in the control group (P<0.05). The total effective rate of treatment and pregnancy rate in the observation group were higher than those in the control group (P<0.05). ConclusionModified Guishen Pills combined with auricular acupoint pressing with bean for the treatment of patients with DOR and concomitant infertility exerts a significant efficacy, which can effectively ameliorate the clinical symptoms, ovarian function, and increase successful rate of pregnancy in patients.

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