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论著·临床研究 | 更新时间:2023-12-22
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打鼾儿童发生OSAS的影响因素及列线图预测模型构建
Influencing factors for the occurrence of OSAS in snoring children and the establishment of nomogram prediction model

广西医学 2023第45卷19期 页码:2331-2334+2360

作者机构:赵启君,硕士,主治医师,研究方向为儿童呼吸性疾病。

基金信息:甘肃省科技计划项目(18JR2FA004);兰州市科技计划项目(2022-5-77)

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  • 参考文献
目的探讨打鼾儿童发生阻塞性睡眠呼吸暂停综合征(OSAS)的危险因素,并构建列线图预测模型。方法选取175例打鼾儿童,根据多导睡眠监测结果将其分为鼾症组(n=122)与OSAS组(n=53)。比较两组患儿的临床资料,采用多因素Logistic回归模型分析打鼾儿童发生OSAS的危险因素,应用R 3.6.3软件的rms程序包构建列线图预测模型并进行验证。结果两组患儿的体质指数、扁桃体肥大情况、腺样体肥大情况、肥胖情况、烟草暴露情况、鼻炎/鼻窦炎病史、打鼾家族史差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,肥胖、扁桃体肥大、腺样体肥大、有鼻炎/鼻窦炎病史是打鼾儿童发生OSAS的危险因素(P<0.05)。基于上述危险因素构建的列线图预测模型具有良好的区分度、校准度和拟合度,对打鼾儿童发生OSAS有一定的预测价值。结论肥胖、扁桃体肥大、腺样体肥大、有鼻炎/鼻窦炎病史是打鼾儿童发生OSAS的危险因素,基于以上危险因素构建的列线图预测模型对打鼾儿童发生OSAS有一定的预测价值。
ObjectiveTo explore the risk factors for the occurrence of obstructive sleep apnea syndrome (OSAS) in snoring children, and to establish a nomogram prediction model. MethodsA total of 175 snoring children were selected, and they were divided into snore symptom group (n=122) or OSAS group (n=53) according to the results of polysomnography. The clinical data were compared between children of the two groups. The risk factors for snoring children suffering from OSAS were analyzed by using the multivariate Logistic regression model. The nomogram prediction model was established and validated by employing the rms package of R 3.6.3 software.ResultsThere were statistically significant differences in body mass index, and statuses of tonsil hypertrophy, adenoid hypertrophy, obesity, tobacco exposure, as well as history of rhinitis/sinusitis, and family history of snoring between the two groups (P<0.05). The results of multivariate Logistic regression analysis revealed that obesity, tonsil hypertrophy, adenoid hypertrophy, the presence of rhinitis/sinusitis history were the risk factors for snoring children suffering from OSAS (P<0.05). The nomogram prediction model established based on the aforesaid risk factors exerted favorable discrimination, calibration, and fitting degree, with predictive value for snoring children suffering from OSAS to a certain extent.ConclusionObesity, tonsil hypertrophy, adenoid hypertrophy, the presence of rhinitis/sinusitis history are the risk factors for snoring children suffering from OSAS, and the nomogram prediction model established based on the aforementioned risk factors exerts predictive value for snoring children suffering from OSAS to a certain extent.

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