ObjectiveTo explore the application effect of extracorporeal diaphragm pacing combined with fibrobronchoscopic alveolar lavage therapy in patients with chronic obstructive pulmonary disease (COPD) undergoing invasive mechanical ventilation. MethodsA total of 140 COPD patients undergoing invasive mechanical ventilation were divided into observation group or control group, with 70 cases in each group. The control group was treated with routine therapy, based on which the observation group was treated with extracorporeal diaphragm pacing combined with fibrobronchoscopic alveolar lavage. The pre- and post-treatment pulmonary function indices with respect to forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) value, maximal voluntary ventilation (MVV), FVC, and respiratory mechanical indices (airway resistance, peak airway pressure, and dynamic lung compliance), arterial blood gas analysis indices (PaO2, PaCO2, arterial oxygen saturation ［SaO2］), serum inflammatory factors (C-reactive protein ［CRP］, procalcitonin, tumor necrosis factor α ［TNF-α］) levels were compared between the two groups. The occurrence of complications during treatment was observed in both groups. ResultsAfter treatment, both groups exhibited improved pulmonary function indices, respiratory mechanical indices, arterial blood gas analysis indices, and serum inflammatory factors levels as compared with before treatment; besides, the observation group yielded higher FEV1/FVC value, MVV, FVC, dynamic lung compliance, PaO2, and SaO2 as compared with the control group, while lower airway resistance, peak airway pressure, PaCO2, and serum CRP, procalcitonin and TNF-α levels as compared with the control group (all P＜0.05). No statistically significant difference in the incidence rates of respiratory tract infection, pneumothorax, ventilator-associated pneumonia, pulmonary injury was found between patients of the two groups (all P＞0.05). ConclusionOn the basis of routine therapy, additionally employing extracorporeal diaphragm pacing combined with fibrobronchoscopic alveolar lavage therapy can effectively ameliorate pulmonary function and respiratory mechanical indices of COPD patients undergoing invasive mechanical ventilation, increase pulmonary ventilation volume, improve hypoxia and CO2 retention in the body, decrease serum inflammatory factors levels, and its effects are superior to those with routine therapy alone, exerting a relatively high safety.

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