ObjectiveTo explore the clinical effect of modified Danggui Xugu Decoction combined with manual reduction and novel splint external fixation for treating patients with distal radius fracture. MethodsA total of 98 patients with distal radius fracture were randomly divided into observation group or control group, with 49 cases in each group. The control group received manual reduction combined with novel splint external fixation for treatment, and the observation group was treated with modified Danggui Xugu Decoction combined with manual reduction and novel splint external fixation. The efficacy, pre- and post-treatment pain mediators (substance P, β-endorphin, serum prostaglandin E2, neuropeptide Y), Gartland-Werley wrist joint score, bone metabolism indices (procollagen type Ⅰ N-terminal propeptide［P1NP］, C-terminal telopeptide of type Ⅰ collagen ［β-CTX］, receptor activator of nuclear factor kappa B ［RANK］, receptor activator of nuclear factor kappa B ligand ［RANKL］, and tartrate-resistant acid phosphatase 5b ［TRACP5b］) were compared between patients of the two groups. ResultsThe total effective rate of the observation group was higher than that of the control group (P＜0.05). After treatment, the levels of serum substance P, β-endorphin, prostaglandin E2, neuropeptide Y, P1NP, β-CTX, and Gartland-Werley wrist joint score were decreased as compared with before treatment, whereas levels of serum RANK, RANKL, and TRACP5b were elevated as compared with before treatment, and the observation group yielded decreased aforesaid indices compared with the control group (all P＜0.05). ConclusionModified Danggui Xugu Decoction combined with manual reduction and novel splint external fixation for the treatment of patients with distal radius fracture exerts a significant effect, which can inhibit osteoclast function, relieve pain, and ameliorate wrist joint function, and its efficacy is superior to manual reduction combined with novel splint external fixation therapy.

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