ObjectiveTo compare the application effect of different incisions in the radical resection of papillary thyroid carcinoma (PTC) in obese females. MethodsSixty obese female patients undergoing radical resection of PTC were randomly divided into conventional collar incision group (Group A) or second neck transverse striation incision group (Group B), with 30 cases in each group. Patients in both groups received standard radical resection of thyroid carcinoma for treatment, group A employed conventional collar incision, and group B took second neck transverse striation as surgical incision. The operation duration, intraoperative bleeding volume, exposure rate of lateral branch of superior laryngeal nerve, degree of postoperative pain, satisfaction with cosmetic effect, postoperative drainage volume, number of lymph node dissection were compared between patients of the two groups. The occurrence of operative complications (injuries to lateral branch of superior laryngeal nerve and recurrent laryngeal nerve) was recorded in patients of both groups. ResultsThere was no statistically significant difference in operation duration, intraoperative bleeding volume, postoperative pain degree score, postoperative drainage volume, number of lymph node dissection between patients of the two groups (P>0.05). Group B exhibited superior exposure rate of lateral branch of superior laryngeal nerve and satisfaction with cosmetic effect to compare with group A (P<0.05). There was 1 case of temporary recurrent laryngeal nerve injury in group A, and 1 case of neck swelling in group B, both of which returned to normal after treatment. ConclusionCompared with collar incision, the use of the second neck transverse striation as surgical incision in the radical resection of PTC for obese female patients can improve cosmetic effect and the exposure rate of lateral branch of superior laryngeal nerve, and does not prolong operation duration, as well as dose not increase intraoperative bleeding volume, with a relatively high safety.