Objective To analyze and summarize Xiaguan (S17) acupoint for the major treatment of diseases and symptoms and acupoint combination rules by employing data mining technique. Methods Relevant literature data was retrieved from database establishment to December 2021 in the China National Knowledge Infrastructure. The data mining analysis was performed on enrolled literature by using the SPSS Modeler 18.0 software and Gephi V0.9.2 software. Results A total of 90 literature was enrolled, therein there was 71 literature with single acupoint application of Xiaguan (S17) acupoint, and 19 literature with the application of combination of other acupoints. Among the 90 enrolled literature, acupuncture had the largest number of research literature. The dominant diseases and symptoms of major treatment of single acupoint of Xiaguan (S17) acupoint were rhinitis, toothache, facial paralysis and facial nerve disease, as well as temporomandibular arthritis and disorders; furthermore, the dominant diseases and symptoms of major treatment of other acupoints combination of Xiaguan (S17) acupoint were prosopalgia, facial paralysis and facial nerve disease, and temporomandibular arthritis and disorders, etc. There were 15 acupoints combined with Xiaguan (S17) acupoint, and they mainly combined with acupoints belonged to Wuwei meridian, Pangguang meridian, and other meridians. Conclusion Single acupoint of Xiaguan (S17) acupoint and Xiaguan (S17) acupoint combined with Neiting (ST44), Sibai (ST2), Cuanzhu (BL2), Yifeng (SJ17), and other acupoints can mainly treat facial diseases and diseases of the nervous system.

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