Objective To explore the expression of peripheral blood CD4+CD25+CD127- regulatory T cell (Treg) in elderly patients with chronic heart failure (CHF) and its estimated value for prognosis. MethodsA total of 93 elderly CHF patients were selected as the research subjects, all patients received routine therapy and regular follow-up for 1 year. The occurrence of cardiovascular adverse events of patients (readmission with worsening heart failure, malignant arrhythmia, nonfatal myocardial infarction) within 1 year of follow-up was recorded, and patients were assigned to adverse prognosis group (30 cases) or favorable prognosis group (63 cases) according to prognostic states. The expression of CD4+CD25+CD127- Treg in peripheral blood, clinical data, and relevant indices with respect to serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) level, platelet counts, hemoglobin level, glomerular filtration rate, left ventricular end diastolic diameter, left ventricular ejection fraction at admission were compared between patients of the two groups. The factors for affecting adverse prognosis of elderly CHF patients were analyzed by using the Logistic regression model. The estimated value of peripheral blood CD4+CD25+CD127- Treg expression on prognosis of elderly CHF patients was analyzed by employing the receiver operating characteristic (ROC) curve. ResultsThe level of serum NT-proBNP of patients in the adverse prognosis group was higher than that in the favorable prognosis group at admission, and the expression of peripheral blood CD4+CD25+CD127- Treg was lower than that in the favorable prognosis group at admission (P＜0.05). At admission, peripheral blood CD4+CD25+CD127- Treg expression in elderly CHF patients negatively correlated with serum NT-proBNP level, and serum NT-proBNP over-expression, peripheral blood CD4+CD25+CD127- Treg low-expression were the risk factors for adverse prognosis of elderly CHF patients (P＜0.05). The results of ROC curve revealed that when the cut-off value of peripheral blood CD4+CD25+CD127- Treg expression was 5.65% at admission, the optimal predictive value could be obtained, and its area under the curve for predicting risk of adverse prognosis in elderly CHF patients was 0.831, the sensitivity was 0.833, the specificity was 0.619, and the Youden index was 0.486. ConclusionPeripheral blood CD4+CD25+CD127- Treg expression is decreased in elderly CHF patients with adverse prognosis, and it may be the influencing factor for adverse prognosis of patients, which can be used to predict prognosis of elderly CHF patients.

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