Objective To analyze the levels of serum mitogen⁃activated protein kinase 1 (MAPK1), tumor necrosis factor α (TNF⁃α) and von Willebrand factor (vWF) in patients with preeclampsia, and their relations with disease severity. Methods A total of 100 patients with preeclampsia and 70 healthy pregnant women (the control group) were enrolled, and patients with preeclampsia were assigned to severe group (46 cases) or mild group (54 cases) according to disease severity. The routine indices (serum creatinine level, serum urea level, blood pressure, 24⁃hour urinary protein content), and serum TNF⁃α, MAPK1, and vWF levels were compared between pregnant women of the three groups. Results The severe and mild groups exhibited higher serum creatinine and urea levels, and higher systolic blood pressure, diastolic blood pressure, 24⁃hour urinary protein content, as well as higher serum TNF⁃α, MAPK1, and vWF levels as compared with the control group, and the aforementioned indices of the severe group were higher than those of the mild group (P<0.05). Conclusion Serum MAPK1, TNF⁃α, and vWF levels are elevated in patients with preeclampsia, and closely related to patients' disease severity. The detection of the aforementioned indices may help to improve the early diagnosis rate of preeclampsia.

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