Patients with acute⁃on⁃chronic liver failure (ACLF) develop rapidly, are often concomitant multiple organ failure, and have a poor prognosis. Liver transplantation plays a crucial role in the treatment of ACLF patients; however, there are still multiple risks associated to patients' postoperative death during treatment. In this paper, clinical practice concerning primary disease treatment, disease evaluation, operation time selection, bridging therapy, donor liver selection, surgical characteristics, postoperative application of immunosuppresant of ACLF is explored, aiming at providing novel direction for optimizing liver transplantation therapy in ACLF patients. 

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