Autism spectrum disorder (ASD) is diseases of neurodevelopmental disorder with high genetic heterogeneity. Except for neurological symptoms, a lot of ASD children usually exhibit concomitant gastrointestinal symptoms. Increasing evidences indicate that the composition of intestinal flora in ASD children changes significantly, and abnormal intestinal flora may be involved in the occurrence and development of ASD through the microbe⁃intestine⁃brain axis. At present, there is no effective drug to ameliorate the core symptoms of ASD. In this review, the potential relation of intestinal microecological flora and its metabolites with ASD, and microecotherapy such as probiotics, prebiotics, and fecal microbiota transplantation in the application values of ASD are summarized, aiming at providing more references for ameliorating the core symptoms of ASD children.

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