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专家账号密码找回目的 系统评价超声清创联合负压封闭引流（VSD）治疗糖尿病足溃疡（DFU）的有效性和安全性。方法 计算机检索中国知网、万方数据知识服务平台、维普资讯中文期刊服务平台、PubMed、Web of Science、Embase、The Cochrane Library等数据库，纳入关于超声清创联合VSD治疗DFU的随机对照研究和队列研究。筛选文献并进行质量评价后，采用Stata/MP 17.0软件行Meta分析，采用TSA 0.9软件行试验序贯分析。结果 共纳入16篇文献，包含1 413例DFU患者，其中试验组（超声清创联合VSD）719例、对照组（常规清创联合VSD）694例。Meta分析结果显示：超声清创联合VSD的总有效率、视觉模拟量表（VAS）评分、住院时间、换药次数、细菌清除率、经皮氧分压和一般不良事件发生率、严重不良事件发生率优于常规清创联合VSD（P<0.05）。试验序贯分析结果提示研究结果具有稳健性。结论 与常规清创联合VSD相比，超声清创联合VSD治疗DFU可获得更高的总有效率，更好地改善创面感染情况和组织氧供，缩短住院时间和减少换药次数，总体安全性更好。
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更新时间：2024-06-18
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超声清创联合负压封闭引流治疗糖尿病足溃疡的Meta分析与试验序贯分析
Meta⁃analysis and trial sequential analysis of ultrasonic debridement combined with vacuum sealing drainage for the treatment of diabetic foot ulcer
广西医学 页码：556-565
作者机构：陈家扬，在读硕士研究生，研究方向为骨科疾病的中西医结合防治。
基金信息：国家自然科学基金（82060874）；广西中医药大学研究生教育创新计划项目（YCSY2023042）
- 中文简介
- 英文简介
- 参考文献
Objective To systematically evaluate the effectiveness and safety of ultrasonic debridement combined with vacuum sealing drainage (VSD) for the treatment of diabetic foot ulcer (DFU). Methods Randomized controlled trials and cohort studies related to ultrasonic debridement combined with VSD for the treatment of DFU were enrolled by retrieving the databases such as China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, VIP, PubMed, Web of Science, Embase, and The Cochrane Library. After literature screening for performing quality evaluation, the Stata/MP 17.0 software was used for Meta⁃analysis, and the TSA 0.9 software was used to perform trial sequential analysis. Results A total of 16 literature was enrolled, including 1413 DFU patients, therein there were 719 cases in the experiment group (ultrasonic debridement combined with VSD), and 694 cases in the control group (routine debridement combined with VSD). The results of Meta⁃analysis revealed that ultrasonic debridement combined with VSD exhibited superior total effective rate, Visual Analogue Scale (VAS) score, length of hospital stay, dressing change frequency, bacterial clearance rate, transcutaneous partial pressure of oxygen, and superior incidence rates of general adverse events and severe adverse events as compared with routine debridement combined with VSD (P<0.05). The results of trial sequential analysis revealed that the research findings exert robustness. Conclusion Compared with routine debridement combined with VSD, ultrasonic debridement combined with VSD for the treatment of DFU can obtain higher total effective rate, and preferably ameliorate wound infection status and tissue oxygen supply, shorten length of hospital stay and dressing change frequency, exerting preferably overall safety.
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