Objective To investigate the potential category features and influencing factors of kinesiophobia in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Methods A total of 360 ACS patients receiving PCI for treatment were selected as the investigation subjects by employing the convenience sampling method. The general information inventory, Tampa Scale for Kinesiophobia⁃Heart (TSK⁃SV Heart), Multidimensional Self‐Efficacy for Exercise Scale (MSES), Impact of Event Scale⁃Revised (IES⁃R), and Social Support Rating Scale (SSRS) were perform on them for investigation. The potential profile analysis was used to explore the potential categories of kinesiophobia in ACS patients after PCI. On the basis of the results of potential category analysis, the influencing factors for kinesiophobia in ACS patients after PCI were analyzed by using the multinomial Logistic regression model. Results The total score of TSK⁃SV Heart among 360 ACS patients was 42.94±7.92, therein 71.1% (256/360) of patients had kinesiophobia. Through potential profile analysis, kinesiophobia in ACS patients after PCI was assigned to the 3 potential categories of low kinesiophobia, medium kinesiophobia, and high kinesiophobia. The results of multinomial Logistic regression analysis revealed that educational level, number of comorbidity, cardiac function classification, type D personality, self⁃efficacy for exercise (MSES total score), impact degree of events (IES⁃R total score), and social support level (SSRS total score) were the influencing factors for different degrees of kinesiophobia in ACS patients after PCI (P<0.05). Conclusion Kinesiophobia of ACS patients after PCI is at a relatively high level, and it has prominent category features. Multiple factors such as self⁃efficacy for exercise, impact degree of events, and social support level can affect kinesiophobia level of ACS patients after PCI. Medical and nursing staff should formulate and implement targeted health guidance and intervention measures according to the features of patients with different types of kinesiophobia, so as to decrease the level of kinesiophobia of patients and improve their positivity for carrying out exercise rehabilitation.