广西医学

目的　基于Web of ScienceTM核心合集数据库，运用文献计量学方法分析线粒体自噬在阿尔茨海默病（AD）领域中的研究热点和研究趋势。方法　在Web of ScienceTM核心合集数据库中检索线粒体自噬与AD的相关文献。利用CiteSpace 6.1.R6软件、CiteSpace 6.2.R3软件、VOSviewer软件、Bibliometric文献计量在线分析平台对文献进行分析，绘制可视化知识图谱。结果　共纳入257篇有关线粒体自噬与AD的文献，年发文量呈现逐年递增趋势。Reddy PH是发文量最多且最具影响力的作者，得克萨斯理工大学是发文量最多的机构，美国是发文量最多的国家。该研究领域的热点关键词包括阿尔茨海默病、氧化应激、β淀粉样蛋白、小鼠模型、线粒体功能障碍等。认知减退、异常相互作用、tau蛋白、parkin介导的线粒体自噬、动力相关蛋白1等是线粒体自噬与AD领域未来的研究趋势。结论　线粒体自噬及相关蛋白与AD发病机制之间的相关性受到越来越多的关注。除β淀粉样蛋白、tau蛋白外，动力相关蛋白1和parkin蛋白亦是线粒体自噬在AD发生、发展中发挥作用的关键蛋白，其所参与的复杂机制有待深入挖掘。

Objective To analyze the research hotspots and tendency of mitophagy in the field of Alzheimer's disease (AD) by employing the bibliometric method based on the Web of ScienceTM Core Collection database. Methods Literature related to mitophagy and AD in the Web of ScienceTM Core Collection database was retrieved. The CiteSpace 6.1.R6 software, CiteSpace 6.2.R3 software, VOSviewer software, and Bibliometric online analysis platform were used to perform literature analysis, and to draw visual knowledge graph. Results A total of 257 literature related to mitophagy and AD was enrolled, and the annual number of literature publications exhibited an increasing trend year by year. Reddy PH was the most published and influential author, Texas Tech University was the most published institution, and the United States of America was the most published country. The hot keywords in this research field contained Alzheimer's disease, oxidative stress, β amyloid protein, mouse model, mitochondrial dysfunction, etc. Cognitive decline, abnormal interaction, tau protein, parkin-mediated mitophagy, and dynamin-related protein 1 were the future research tendency in the field of mitophagy and AD. Conclusion The correlation of mitophagy and related proteins with pathogenesis of AD has attracted more and more attention. In addition to β amyloid protein and tau protein, dynamin-related protein 1 and parkin protein are also the key proteins of mitophagy in the occurrence and development of AD, and the complex mechanism involved in them need to be further explored.

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