Objective To analyze the medication rules of Traditional Chinese Medicine for the treatment of periarthritis humeroscapularis based on data mining technique. Methods Clinical research literature of oral use and application therapy of Traditional Chinese Medicine for the treatment of periarthritis humeroscapularis was collected by retrieving China National Knowledge Infrastructure, VIP, Wanfang Data Knowledge Service Platform, and the retrieval time was from January, 2010 to September, 2023. Use frequency statistics, use frequency statistics of property, flavor, meridian and effect, and analyses of association rule and cluster were performed on concerning drugs. Results (1) A total of 244 prescriptions of Traditional Chinese Medicine oral use for the treatment of periarthritis humeroscapularis. The effects were mainly drugs of tonifying deficiency and expelling wind-dampness, properties of drugs were mainly warm, flavors of drugs were mainly bitter and acrid, and meridians mainly belonged to liver meridian, spleen meridian, and kidney meridian. The association rule analysis obtained 5 groups of two⁃drug combination, 8 groups of three⁃drug combination, and 1 group of four⁃drug combination; furthermore, the core drugs contained licorice, Radix paeoniae alba, Angelica sinensis, Chuanxiong rhizoma, Saposhnikoviae radix, Hedysarum multijugum, Cinnamomi ramulus, and Asari radix et rhizoma, etc. The cluster analysis acquired 3 groups of effective clusters. (2) A total of 245 prescriptions of Traditional Chinese Medicine application therapy for the treatment of periarthritis humeroscapularis were screened out. The effects were mainly drugs of expelling wind⁃dampness and promoting blood circulation to remove stagnation, properties of drugs were mainly warm, flavors of drugs were mainly bitter and acrid, and meridians mainly belonged to liver meridian, spleen meridian, and kidney meridian. The association rule analysis obtained 4 groups of two⁃drug combination, and 5 groups of three⁃drug combination; furthermore, the core drugs included Aconitum kusnezoffii reichb, Aconiti radix, Myrrha, Olibanun, Notopterygii rhizoma et radix, and Carthami flos, etc. The cluster analysis acquired 5 groups of effective clusters. Conclusion Gegen Decoction and Duhuo Jisheng Decoction are the main Traditional Chinese Medicines which are used for the oral treatment of periarthritis humeroscapularis. Modified Gegen Decoction can be selected to treat periarthritis humeroscapularis mainly caused by external infection, and modified Duhuo Jisheng Decoction can be used for the treatment of periarthritis humeroscapularis mainly caused by liver and kidney insufficiency. For application therapy of Traditional Chinese Medicine, drugs with combination of herbal ingredients of promoting blood circulation to remove stagnation, expelling wind⁃dampness, and releasing exterior are mainly selected, so as to ameliorate patients' symptoms.

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