Objective To investigate the expression of cyclin⁃dependent kinase inhibitor 3 (CDKN3) in laryngeal squamous cell carcinoma (LSCC) tissues, and to analyze its relation with clinicopathological features and prognosis of LSCC patients. Methods Cancerous and corresponding paracancerous normal tissues of 83 LSCC patients were collected, and the expression of CDKN3 in tissues was detected by using the immunohistochemical method. CDKN3 expression in LSCC tissues was compared between patients with different clinicopathological features, and the overall survival rate was compared between patients with different CDKN3 expressions. According to patients' survival status, they were assigned to death group (n=11) or survival group (n=72), clinicopathological features and CDKN3 expression in LSCC tissues were compared between the two groups. The influencing factors for LSCC patients' survival status were analyzed by employing the Logistic regression model. Results CDKN3 expression in LSCC tissues was higher than that in paracancerous normal tissues (P<0.05). Patients with TNM stage in Ⅲ+Ⅳ, stage in T3+T4, and with the presence of lymph node metastasis obtained a higher CDKN3 expression in LSCC tissues (P<0.05). The overall survival rate of patients with low⁃expressed CDKN3 was higher than that of patients with high⁃expressed CDKN3 (P<0.05). The survival group exhibited higher proportions of patients with TNM stage in Ⅰ+Ⅱ, without lymph node metastasis, with stage in T1+T2, and with CDKN3 expression<0.029 as compared with the death group (P<0.05). The results of multivariate Logistic regression analysis indicated that lymph node metastasis was the influencing factor for affecting LSCC patients' survival status (P<0.05). Conclusion CDKN3 expression is elevated in LSCC tissues, its expression is related to patients' clinical stage and lymph node metastasis, and the overall survival rate of patients with high⁃expressed CDKN3 is relatively low.

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