Objective　To systematically evaluate the safeness and effectiveness of postoperative early enteral nutrition (EEN) in children with congenital duodenal obstruction (CDO). Methods　The randomized controlled trials and retrospective cohort studies related to postoperative EEN in CDO children were enrolled by retrieving the databases of The Cochrane Library, Web of Science, PubMed, EBSCO, China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, and VIP, etc. After screening, data extracting, and quality evaluating of the enrolled literature, the RevMan 5.4 software was employed to perform Meta⁃analysis. Results　A total of 6 literature was enrolled, containing 307 CDO children, therein there were 145 cases in the EEN group, and 162 cases in the delayed enteral nutrition (DEN) group. The results of Meta⁃analysis revealed that compared with the DEN group, the EEN group exhibited shorter length of hospital stay, time to postoperative parenteral nutrition use, and time to postoperative total enteral nutrition achieved (P<0.05). There was no statistically significant difference in the incidence rate of vomiting between the two groups (P>0.05). No cases of necrotizing enterocolitis (NEC) or sepsis was reported in any of the studies. Conclusion EEN after 24 hours to 48 hours of operation is helpful for shortening length of hospital stay, postoperative time to parenteral nutrition use, and time to total enteral nutrition achieved in CDO children, and it does not increase the occurrence risk of complications in terms of NEC and sepsis, etc.

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