ObjectiveTo explore the influencing factors for ICU-acquired weakness (ICU-AW) in patients with severe pneumonia. MethodsThe clinical data of 122 patients with severe pneumonia were collected, and they were assigned to ICU-AW group (n=51) or non ICU-AW group (n=71) according to presence of ICU-AW. The clinical data were compared between the two groups. The multivariate Logistic regression model was employed to analyze the influencing factors for patients with severe pneumonia suffering from ICU-AW. ResultsThe incidence rate of ICU-AW in patients with severe pneumonia was 41.8% (51/122). There were statistically significant differences in age, Acute Physiology and Chronic Health Evaluation Ⅱ (APACHEⅡ) score within 24 hours after admission to ICU, mechanical ventilation duration, length of ICU stay, sedation and analgesic time, and occurrence of sepsis, hyperglycemia, multiple organ dysfunction syndrome, hypoproteinemia, delirium, as well as use of norepinephrine, neuromuscular blocking agents, and braking conditions between the ICU-AW group and the non ICU-AW group (P＜0.05). The results of multivariate Logistic regression analysis revealed that age, APACHEⅡ score within 24 hours after admission to ICU, mechanical ventilation duration, sedation and analgesic time, occurrence of sepsis, use of neuromuscular blocking agents, and braking conditions were the influencing factors for patients with severe pneumonia suffering from ICU-AW (P＜0.05). ConclusionThe incidence rate of ICU-AW is relatively high in patients with severe pneumonia, severe pneumonia patients with age≥60 years old, APACHEⅡ score within 24 hours after admission to ICU≥15 points, mechanical ventilation duration≥7 days, sedation and analgesic time≥7 days, sepsis occurrence, use of neuromuscular blocking agents, and with braking have increased risk of suffering from ICU-AW.

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