广西医学

目的探讨寻常型银屑病（PV）患者血清miR⁃146a与miR⁃196a的表达水平及其临床意义。方法选取100例PV患者作为PV组，选择100例同期参加体检的健康志愿者作为NC组。比较治疗前两组研究对象血清miR⁃146a和miR⁃196a的表达水平，以及治疗前后PV组血清miR⁃146a和miR⁃196a的表达水平。根据皮损面积及严重程度指数（PASI）评分、银屑病的分期分别将PV组患者分为轻度组（n=37）、中度组（n=35）、重度组（n=28），以及进行期组（n=33）、静止期组（n=42）、退行期组（n=25），比较不同亚组PV患者治疗前血清miR⁃146a和miR⁃196a的表达水平。采用Spearman相关性分析探讨血清miR⁃146a及miR⁃196a表达水平与PASI评分的相关性。结果与NC组相比，PV组血清miR⁃146a表达水平升高，血清miR⁃196a表达水平降低（P<0.05）。治疗前，轻度组、中度组、重度组PV患者血清miR⁃146a表达水平依次升高，血清miR⁃196a表达水平依次降低（P<0.05）；进行期组、静止期组、退行期组PV患者血清miR⁃146a表达水平依次降低，血清miR⁃196a表达水平依次升高（P<0.05）。PV患者血清miR⁃146a表达水平与PASI评分呈正相关，血清miR⁃196a表达水平与PASI评分呈负相关（P<0.05）。治疗后，PV患者血清miR⁃146a表达水平较治疗前降低，血清miR⁃196a表达水平较治疗前升高（P<0.05）。结论 PV患者血清miR⁃146a表达水平升高，血清miR⁃196a表达水平降低，二者与病情严重程度及疾病分期密切相关。

Objective To explore the expressions of serum miR⁃146a and miR⁃196a in patients with psoriasis vulgaris (PV) and their clinical significance. Methods A total of 100 PV patients were selected as the PV group, and 100 healthy volunteers undergoing physical check⁃up during the same period as the NC group. Serum miR⁃146a and miR⁃196a expressions were compared between research subjects in the two groups before treatment, and serum miR⁃146a and miR⁃196a expressions in the PV group were compared between before and after treatment. According to score of Psoriasis Area and Severity Index (PASI) score and psoriasis stages, patients of the PV group were assigned to mild group (n=37), moderate group (n=35), severe group (n=28), as well as active stage group (n=33), resting stage group (n=42), or regression stage group (n=25), respectively. Serum miR⁃146a and miR⁃196a expressions were compared between PV patients in the various subgroups before treatment. The Spearman correlation analysis was used to explore the correlation of serum miR⁃146a and miR⁃196a expressions with PASI score. Results Compared with the NC group, the PV group exhibited an elevated serum miR⁃146a expression, while a decreased serum miR⁃196a expression (P<0.05). Before treatment, serum miR⁃146a expression was elevated in PV patients of the mild, moderate and severe groups successively, whereas serum miR⁃196a expression was decreased successively (P<0.05); furthermore, serum miR⁃146a expression was decreased in PV patients of the active stage, resting stage, and regression stage groups successively, while serum miR⁃196a expression was elevated successively (P<0.05). Serum miR⁃146a expression of PV patients positively correlated with PASI score, whereas serum miR⁃196a expression negatively correlated with PASI score (P<0.05). After treatment, serum miR⁃146a expression was decreased, whereas serum miR⁃196a expression was elevated as compared with before treatment (P<0.05). Conclusion Serum miR⁃146a expression is elevated, while serum miR⁃196a expression is decreased in PV patients. The two indices as above are closely related to disease severity and stage.