Objective To systematically evaluate the efficacy and safety of vertebroplasty assisted by 3D printed guided⁃plate for the treatment of osteoporotic vertebral compression fracture. Methods Literature related to vertebroplasty assisted by 3D printed guided⁃plate for the treatment of osteoporotic vertebral compression fracture was collected by retrieving the databases of China National Knowledge Infrastructure, Wanfang Database Knowledge Service Platform, Chinese Biomedical Literature Service System, VIP, Embase, PubMed, and The Cochrane Library, etc. After literature screening, data extraction and quality evaluation, the RevMan 5.4 software was used to perform Meta analysis. Results A total of 11 literature was enrolled. The results of Meta⁃analysis revealed that compared with the convention group, the guided⁃plate group exhibited shorter operation duration, less intraoperative perspective frequency, and a lower incidence rate of complications (P<0.05), but there was no statistically significant difference in Visual Analogue Scale score for pain, postoperative Oswestry disability index score, and the amount of bone cement injection between the two groups (P>0.05). Conclusion Vertebroplasty assisted by 3D printed guided⁃plate for the treatment of osteoporotic vertebral compression fracture can shorten operation duration, reduce intraoperative perspective frequency, decrease incidence rate of complications, exerting favorable clinical application values.