Objective To observe the clinical effect of massage integrated by disease diagnosis and syndrome differentiation for the treatment of chronic fatigue syndrome. Methods A total of 95 patients with chronic fatigue syndrome were randomly assigned to observation group (n=48) or control group (n=47). Patients of the observation group received massage therapy integrated by disease diagnosis and syndrome differentiation, whereas the control group was orally administrated Oryzanol Tablets and Compound Vitamin B Tablets for treatment. The clinical efficacy of the two groups was evaluated after 4 weeks of treatment. The Fatigue Assessment Instrument (FAI), Symptom Check List⁃90 (SCL⁃90), and 36⁃Item Short⁃Form Health Survey (SF⁃36) scores were compared between the two groups before treatment and 4 weeks after treatment. Results　After 4 weeks of treatment, there were 9 cases of clinical recovery, 23 cases of excellence, 11 cases of effectiveness, and 5 cases of ineffectiveness in the observation group, and cases of clinical recovery, excellence, effectiveness, and ineffectiveness of the control group were 3, 10, 20, and 24, respectively; furthermore, the observation group yielded superior clinical efficacy to compare with the control group (P<0.05). After 4 weeks of treatment, the observation group exhibited decreased FAI score and SCL⁃90 score as compared with before treatment, while an increased SF⁃36 score as compared with before treatment, and scores as above in the observation group were superior to those in the control group (P<0.05). Conclusion　Massage therapy integrated by disease diagnosis and syndrome differentiation can effectively relieve fatigue degree in patients with chronic fatigue syndrome, ameliorate their mental health status, improve quality of life in patients, exerting a superior effect to routine Western Medicine therapy.

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