ObjectiveTo investigate the application effect of remimazolam on general anesthesia in children with dental caries during oral daytime surgery.MethodsEighty children with dental caries who underwent oral daytime surgery via general anesthesia were randomly divided into propofol group (group P) or remimazolam group (group R), with 40 cases in each group. Group P received intravenous injection of alfentanil in 50 μg/kg plus propofol in 2 mg/kg plus rocuronium bromide in 0.6 mg/kg for anesthesia induction, whereas group R received intravenous injection of alfentanil in 50 μg/kg plus remimazolam in 0.3 mg/kg plus rocuronium bromide in 0.6 mg/kg for anesthesia induction. Children in both groups received nasal tracheal catheterization when a satisfactory degree of muscle relaxation was achieved. During anesthesia maintenance period, continuously intravenous injection of propofol in 6 mg/(kg·h) plus alfentanil in 20-40 μg/(kg·h), remimazolam in 1 mg/(kg·h) plus alfentanil in 20-40 μg/(kg·h) were given to children of the groups P and R, respectively, and intraoperative bispectral index value was maintained between 40 and 60. Operation status with respect to operation duration, intraoperative infusion volume, intraoperative bleeding volume, postoperative tracheal catheter indwelling time, dosage of alfentanil, and length of stay in anesthesia recovery room, Ramsay sedation scale score after tracheal extubation, Facial, Legs, Activity, Crying, Consolability (FLACC) scale score, condition of remedial analgesia, Pediatric Anesthesia Emergence Delirium (PAED) scale score, as well as incidence rate of anesthesia emergence agitation and occurrence of adverse reactions during perioperative period were recorded in children of the two groups. ResultsChildren in group R obtained shorter postoperative tracheal catheter indwelling time and length of stay in anesthesia recovery room as compared with children in group P, and a higher Ramsay sedation scale score, whereas lower PAED scale score, incidence rate of anesthesia emergence agitation, and incidence rate of hypotension as compared with group P (P＜0.05), but there was no statistically significant difference in the remaining observed indices between the two groups (P＞0.05). ConclusionCompared with propofol, remimazolam can effectively shorten tracheal catheter indwelling time and length of stay in anesthesia recovery room in children with dental caries after oral daytime surgery, increase sedation depth, reduce the incidence rate of anesthesia emergence agitation, with a favorable safety.

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